Codexis研发新的诊断酶
2017年1月6日：世界领先的生物催化酶开发供应者Codexis宣布公司将会提供使用下一代测序 （NGS）和PCR的体外诊断的客户提供高性能酶。Codexis的首个专利酶是用于该市场帮助NGS使用者提高文库构建的，预计在2017年第二季度进入实验。
Gingko Bioworks收购Gen9
2017年1月20日：Ginkgo Bioworks宣布收购合成DNA提供者Gen9，但并没有披露价格。Gingko
将为多个行业的运用，提高其对新型有机体设计的速度和能力。本次收购将使Gen9从组装合成DNA
专家转变为自动化生物工程的铸造工厂。
c-LEcta接手Denarase®市场和分销
2017年1月26日：一家德国莱比锡的工业生物技术公司c-LEcta宣布2016年底该公司已从
Sartorius Stedim GmbH接手了Denarase®的分销。Denarase®是一种来自于粘质沙雷氏菌
（Serratia marcescens）的基因工程核酸内切酶，能够非常有效地切割所有形式的DNA和RNA，是
生物技术中常用的定量去除核酸和降低粘度的酶。
诺维信赢得中国专利案件
2017年2月17日：经过旷日持久的官司，诺维信赢得了两个中国企业专利侵权案件。中国最高
人民法院决定审判诺维信与山东龙达生物制品有限公司（Longda Bio-Products Co.）和江苏生物
产品有限公司（Jiangsu Bioproducts Co.）的案件胜诉。诺维信在2013年的时候控告这两家公司
侵犯了其一个糖化酶的专利，可获得170万人民币的赔偿。但这两家公司进行了上诉并且质疑诺维
信专利的有效性。通过几个级别的法院，最后到达了中国最高人民法院，决定坚持诺维信专利的有
效性。这是最终裁决，不能上诉。
会议预告
1）2017年3月6日-8日，有机过程的研究和开发，帕萨迪纳，美国；
https://scientificupdate.co.uk/index.php/conferences/conferences-and-
workshops/details/297-Organic-Process-Research-and-Development-Europe.html
2）2017年5月16日-18日Informex贸易展览和会议，宾夕法尼亚州费城，美国；
3）2017年7月9日-13日，Biotrans 2017，匈牙利布达佩斯；
最新发表文献摘选：
Expression of a codon-optimized β-glucosidase from Cellulomonas
flavigena PR-22 in Saccharomyces cerevisiae for bioethanol production from cellobiose.
Ríos-Fránquez FJ, González-Bautista E, Ponce-Noyola T, Ramos-Valdivia AC, Poggi-Varaldo HM, García-Mena
J, Martinez A. Arch Microbiol. 2017 Jan 30. doi: 10.1007/s00203-016-1333-2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28138738
Converting Pasteurella multocida α2-3-sialyltransferase 1 (PmST1) to a
regioselective α2-6-sialyltransferase by saturation mutagenesis and
regioselective screening.
McArthur JB, Yu H, Zeng J, Chen X. Org Biomol Chem. 2017 Jan 30. doi:
10.1039/c6ob02702d. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28134951
Stereoselective biotransformation of racemic mandelic acid using
immobilized laccase and (S)-mandelate dehydrogenase.
Chen X, Yang C, Wang P, Zhang X, Bao B, Li D, Shi R. Bioresour Bioprocess. 2017;4
(1):2. doi: 10.1186/s40643-016-0135-3.
https://www.ncbi.nlm.nih.gov/pubmed/28133593
Biosynthesis of enantiopure (S)-3-hydroxybutyrate from glucose through
the inverted fatty acid β-oxidation pathway by metabolically engineered
Escherichia coli.
Gulevicha AY, Skorokhodovaa AY, Sukhozhenkoa AV, Debabova VG. J Biotechnol. 2017 Jan
25. pii: S0168-1656(17)30026-3. doi: 10.1016/j.jbiotec.2017.01.009. [Epub ahead of
print]
https://www.ncbi.nlm.nih.gov/pubmed/28131860
Production and Characterization of Organic Solvent-Tolerant Cellulase
from Bacillus amyloliquefaciens AK9 Isolated from Hot Spring.
Irfan M, Tayyab A, Hasan F, Khan S, Badshah M, Shah AA. Appl Biochem Biotechnol. 2017
Jan 27. doi: 10.1007/s12010-017-2405-8. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28130767
Structural and biochemical studies of novel aldo-keto reductases for the
biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol.
Kim T, Flick R, Brunzelle J, Singer A, Evdokimova E, Brown G, Joo JC, Minasov GA,
Anderson WF, Mahadevan R, Savchenko A, Yakunin AF. Appl Environ Microbiol. 2017 Jan
27. pii: AEM.03172-16. doi: 10.1128/AEM.03172-16. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28130301
Identification and characterization of a novel N-acyl-homoserine
lactonase gene in Sphingomonas ursincola isolated from industrial
cooling water systems.
Morohoshi T, Sato N, Iizumi T, Tanaka A, Ikeda T. J Biosci Bioeng. 2017 Jan 24. pii:
S1389-1723(16)30350-4. doi: 10.1016/j.jbiosc.2016.12.010. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28129983
Specificity and mechanism of mandelamide hydrolase catalysis.
Adediran SA, Wang PF, Shilabin AG, Baron CA, McLeish MJ, R F Pratt. Arch Biochem
Biophys. 2017 Jan 24. pii: S0003-9861(16)30577-X. doi: 10.1016/j.abb.2017.01.010.
[Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28129982
Different specificities of two aldehyde dehydrogenases from
Saccharomyces cerevisiae var boulardii.
Datta S, Annapore US, Timson DJ. Biosci Rep. 2017 Jan 26. pii: BSR20160529. doi:
10.1042/BSR20160529. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28126723
Crystal Structure and Functional Characterization of an Esterase (EaEST)
from Exiguobacterium antarcticum.
Lee CW, Kwon S, Park SH, Kim BY, Yoo W, Ryu BH, Kim HW, Shin SC, Kim S, Park H, Kim
TD, Lee JH. PLoS One. 2017 Jan 26;12(1):e0169540. doi: 10.1371/journal.pone.0169540.
https://www.ncbi.nlm.nih.gov/pubmed/28125606
ANCUT2, a Thermo-alkaline Cutinase from Aspergillus nidulans and Its
Potential Applications.
Bermúdez-García E, Pe?a-Montes C, Castro-Rodríguez JA, González-Canto A, Navarro-Oca?
a A, Farrés A. Appl Biochem Biotechnol. 2017 Jan 25. doi: 10.1007/s12010-016-2378-z.
[Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28124733
Heterologous expression and enzymatic characterization of γ-
glutamyltranspeptidase from Bacillus amyloliquefaciens.
Lee JM, Lee J, Nam GH, Son BS, Jang MU, Lee SW, Hurh BS, Kim TJ. J Microbiol. 2017
Feb;55(2):147-152. doi: 10.1007/s12275-017-6638-6.
https://www.ncbi.nlm.nih.gov/pubmed/28120195
A bacterial GH6 cellobiohydrolase with a novel modular structure.
Cerda-Mejía L, Valenzuela SV, Frías C, Diaz P, Pastor FI. Appl Microbiol Biotechnol.
2017 Jan 25. doi: 10.1007/s00253-017-8129-4. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28120014
Engineering 7?-Hydroxysteroid Dehydrogenase for Enhanced Ursodeoxycholic
Acid Production by Multiobjective Directed Evolution.
Zheng MM, Chen KC, Wang RF, Li H, Li CX, Xu JH. J Agric Food Chem. 2017 Feb 3. doi:
10.1021/acs.jafc.6b05428. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28116898
Catechol Removal from Aqueous Media Using Laccase Immobilized in
Different Macro- and Microreactor Systems.
Tu?ek AJ, ?ali? A, Zeli? B. Appl Biochem Biotechnol. 2017 Jan 23. doi:
10.1007/s12010-017-2419-2. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28116574
Biodegradation of polycyclic aromatic hydrocarbons (PAHs) by fungal
enzymes: A review.
Kadri T, Rouissi T, Kaur Brar S, Cledon M, Sarma S, Verma M. J Environ Sci (China).
2017 Jan;51:52-74. doi: 10.1016/j.jes.2016.08.023. Review.
https://www.ncbi.nlm.nih.gov/pubmed/28115152
Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid
biosynthesis.
Zou Y, Garcia-Borràs M, Tang MC, Hirayama Y, Li DH, Li L, Watanabe K, Houk KN, Tang
Y. Nat Chem Biol. 2017 Jan 23. doi: 10.1038/nchembio.2283. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28114276
A novel thermophilic and halophilic esterase from Janibacter sp. R02,
the first member of a new lipase family (Family XVII).
Castilla A, Panizza P, Rodríguez D, Bonino L, Díaz P, Irazoqui G, Rodríguez Giordano
S. Enzyme Microb Technol. 2017 Mar;98:86-95. doi: 10.1016/j.enzmictec.2016.12.010.
https://www.ncbi.nlm.nih.gov/pubmed/28110668
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and
Mechanistically Diverse.
Agarwal V, Miles ZD, Winter JM, Eustáquio AS, El Gamal AA, Moore BS. Chem Rev. 2017
Jan 20. doi: 10.1021/acs.chemrev.6b00571. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28106994
A peroxygenase from Chaetomium globosum catalyzes the selective
oxygenation of testosterone.
Kiebist J, Schmidtke KU, Zimmermann J, Kellner H, Jehmlich N, Ullrich R, Z盲nder D,
Hofrichter M, Scheibner K. Chembiochem. 2017 Jan 19. doi: 10.1002/cbic.201600677.
[Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28103392
A Novel Multi-domain High Molecular, Salt-Stable Alkaline Xylanase from
Alkalibacterium sp. SL3.
Wang G, Wu J, Yan R, Lin J, Ye X. Front Microbiol. 2017 Jan 4;7:2120. doi:
10.3389/fmicb.2016.02120.
https://www.ncbi.nlm.nih.gov/pubmed/28101084
An overview of aldehyde oxidase: an enzyme of emerging importance in
novel drug discovery.
Rashidi MR, Soltani S. Expert Opin Drug Discov. 2017 Jan 17. doi:
10.1080/17460441.2017.1284198. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28095715
Transferase Versus Hydrolase: The Role of Conformational Flexibility in
Reaction Specificity.
Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S,
Freitag NE, Anderson WF. Structure. 2017 Jan 5. pii: S0969-2126(16)30397-5. doi:
10.1016/j.str.2016.12.007. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28089449
Identification and characterization of L-lysine decarboxylase from
Huperzia serrata and its role in the metabolic pathway of lycopodium
alkaloid.
Xu B, Lei L, Zhu X, Zhou Y, Xiao Y. Phytochemistry. 2017 Jan 12. pii: S0031-9422(16)
30307-7. doi: 10.1016/j.phytochem.2016.12.022. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28089246
Xenobiology meets enzymology: Exploring the potential of unnatural
building blocks in biocatalysis.
Budisa N, V枚ller JS, Koksch B, Acevedo-Rocha CG, Kubyshkin V, Agostini F. Angew Chem
Int Ed Engl. 2017 Jan 13. doi: 10.1002/anie.201610129. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/28085996
本文版权归Sustainable Chemistry Solutions与宁波酶赛生物工程有限公司共同所有，未经允许不得转载。